PCa showed significantly increased fractional volume of epithelium (48.8±9.2vs 23.2±7.1) and reduced fractional volumes of lumen (14.0±5.2 vs 26.4±14.1%) and stroma (37.2±9.1 vs 50.5±15.7%) compared to normal prostate tissue.
Correlation with Gleason score: Volumes of tissue components (Epithelium: 0.652, Stroma: -0.439, Lumen: ρ = -0.390) show significantly higher correlation with Gleason score compared to T2 (-0.292) and ADC (-0.315).
Improved diagnostic accuracy (ROC analysis for differentiating PCa from normal prostate): Epithelium (0.991),Lumen (0.800), Stroma volume (0.789).
60 years old patient with Gleason 4+5 cancer in right PZ identified by HM-MRI
Transition zone: false positives based on mpMRI, whereas HM-MRIshows no false-positives